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Beneficial effects of microwave-induced argon plasma treatment on cellular behaviors of articular chondrocytes onto nanofibrous Silk fibroin mesh

Title
Beneficial effects of microwave-induced argon plasma treatment on cellular behaviors of articular chondrocytes onto nanofibrous Silk fibroin mesh
Authors
Jin S.C.Baek H.S.Yeonwoo ILee M.H.Kim J.-S.Park J.-C.Park Y.H.Rah D.K.Chung K.-H.Lee S.J.Han I.H.
Ewha Authors
이승진
SCOPUS Author ID
이승진scopus
Issue Date
2009
Journal Title
Macromolecular Research
ISSN
1598-5032JCR Link
Citation
vol. 17, no. 9, pp. 703 - 708
Indexed
SCI; SCIE; SCOPUS; KCI WOS scopus
Abstract
Silk fibroin scaffolds were examined as a biomaterial option for tissue-engineered cartilage-like tissue. In tissue engineering for cartilage repair using a scaffold, initial chondrocyte-material interactions are important for the following cell behaviors. In this study, the surface of nanofibrous silk fibroin (NSF) meshes was modified by a microwave-induced argon plasma treatment in order to improve the cytocompatibility of the meshes used as cartilaginous grafts. In addition, the effects of a plasma treatment on the cellular behavior of chondrocytes on NSF were examined. The plasma treatment resulted in an increase in the hydrophilicity of NSF meshes suggesting that the cytocompatibility of the mesh might be improved. Furthermore, the human articular chondrocytes showed higher viability on the surface-modified NSF meshes. These results suggest that the surface modification of NSF meshes by plasma can enhance the cellular behavior of chondrocytes and may be used in tissue engineering.
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약학대학 > 약학과 > Journal papers
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