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Bacterial-modulated host immunity and stem cell activation for gut homeostasis

Title
Bacterial-modulated host immunity and stem cell activation for gut homeostasis
Authors
Lee W.-J.
Ewha Authors
이원재
Issue Date
2009
Journal Title
Genes and Development
ISSN
0890-9369JCR Link
Citation
vol. 23, no. 19, pp. 2260 - 2265
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Although it is widely accepted that dynamic cross-talk between gut epithelia and microorganisms must occur to achieve gut homeostasis, the critical mechanisms by which gut-microbe interactions are regulated remain uncertain. In this issue of Genes & Development, Buchon and colleagues (pp. 2333-2344) revealed that the reaction of the gut to microorganisms is not restricted to activating immune systems, but extends to integrated responses essential for gut tissue homeostasis, including self-renewal and the differentiation of stem cells. Further investigation of the connection between immune response and stem cell regulation at the molecular level in the microbe-laden mucosal epithelia will accelerate our understanding of the regulatory mechanisms of gut homeostasis and of the pathogenesis of diseases such as chronic inflammatory diseases and colorectal cancers. © 2009 by Cold Spring Harbor Laboratory Press.
DOI
10.1101/gad.1858709
Appears in Collections:
일반대학원 > 바이오융합과학과 > Journal papers
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