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Alteration of sphingolipid metabolism and pSTAT3 expression by dietary cholesterol in the gallbladder of hamsters

Title
Alteration of sphingolipid metabolism and pSTAT3 expression by dietary cholesterol in the gallbladder of hamsters
Authors
Shin H.-W.Kim D.Lee Y.Yoo H.-S.Lee B.J.Kim J.S.Jang S.Lim H.Oh S.
Ewha Authors
오세관
SCOPUS Author ID
오세관scopus
Issue Date
2009
Journal Title
Archives of Pharmacal Research
ISSN
0253-6269JCR Link
Citation
vol. 32, no. 9, pp. 1253 - 1262
Indexed
SCIE; SCOPUS; KCI WOS scopus
Abstract
Cholesterol and sphingolipids are major lipid constituents of the plasma membrane and have been implicated in a number of human diseases, such as atherosclerosis, fatty liver, diabetes mellitus, coronary heart disease, and hypertension. However, the relationship between cholesterol and sphingolipid metabolism has not been investigated. The purpose of this study was to determine whether dietary cholesterol would induce the alteration of sphingolipid metabolism in hamsters. Hypercholesterolemia was induced in hamsters by placing them on an experimental diet containing 0.5% cholesterol plus 0.5% choline chloride for 8 and 12 weeks. The serum profile of the hamsters showed that the administration of cholesterol increased the levels of total cholesterol, LDL cholesterol, and triglycerides as well as the activities of GOT and GPT. The levels of ceramide and sphingosine-1-phosphate (So-1-P) were remarkably elevated by 6-fold, respectively, in the bile juice of cholesterol-fed hamsters. Interestingly, the levels of iNOS and GFAP were increased in the gallbladders of cholesterol-fed hamsters. In addition, the immunostaining of pSTAT3 was increased on the gallbladder epithelium after cholesterol feeding. These results suggest that sphingolipid metabolism may be regulated in the bile juice during cholesterol feeding and may be a potential target for the treatment of hypercholesterolemia-induced diseases. © 2009 The Pharmaceutical Society of Korea and Springer Netherlands.
DOI
10.1007/s12272-009-1911-9
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의학전문대학원 > 의학과 > Journal papers
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