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The first case of antibiotic-associated colitis by Clostridium difficile PCR Ribotype 027 in Korea

Title
The first case of antibiotic-associated colitis by Clostridium difficile PCR Ribotype 027 in Korea
Authors
Tae C.H.Jung S.-A.Song H.J.Kim S.-E.Choi H.J.Lee M.Hwang Y.Kim H.Lee K.
Ewha Authors
이미애정성애최희정김성은
SCOPUS Author ID
이미애scopus; 정성애scopus; 최희정scopus; 김성은scopus
Issue Date
2009
Journal Title
Journal of Korean Medical Science
ISSN
1011-8934JCR Link
Citation
vol. 24, no. 3, pp. 520 - 524
Indexed
SCI; SCIE; SCOPUS; KCI WOS scopus
Abstract
Clostridium difficile (C. difficile) is a common causative agent of pseudomembranous colitis (PMC). C. difficile-associated diarrhea (CDAD) ranges from mild diarrhea to life threatening PMC. Recently, a highly virulent strain of C. difficile polymerase chain reaction ribotype 027 was found in North America, Europe, and Japan. A 52-yr-old woman with anti-tuberculosis medication and neurogenic bladder due to traffic accident experienced five episodes of C. difficile PMC after taking antibiotics for pneumonia along with septic shock and acute renal failure. She was readmitted to the intensive care unit and treated with oral vancomycin with refractory of oral metronidazole, inotropics and probiotics for over 60 days. C. difficile isolated both at the first and the last admission was identified as C. difficile ribotype 027 by ribotyping, toxinotyping, and tcdC gene sequencing, which turned out the same pathogen as the epidemic hypervirulent B1/NAP1 strain. This is the first case of C. difficile PCR ribotype 027 in Korea. After discharge, she was maintained on probiotics and rifaximin for 3 weeks. She had no relapse for 6 months. © The Korean Academy of Medical Sciences.
DOI
10.3346/jkms.2009.24.3.520
Appears in Collections:
의학전문대학원 > 의학과 > Journal papers
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