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The first case of antibiotic-associated colitis by Clostridium difficile PCR Ribotype 027 in Korea
- The first case of antibiotic-associated colitis by Clostridium difficile PCR Ribotype 027 in Korea
- Tae C.H.; Jung S.-A.; Song H.J.; Kim S.-E.; Choi H.J.; Lee M.; Hwang Y.; Kim H.; Lee K.
- Ewha Authors
- 이미애; 정성애; 최희정; 김성은
- SCOPUS Author ID
- 이미애; 정성애; 최희정; 김성은
- Issue Date
- Journal Title
- Journal of Korean Medical Science
- Journal of Korean Medical Science vol. 24, no. 3, pp. 520 - 524
- SCI; SCIE; SCOPUS; KCI
- Document Type
- Clostridium difficile (C. difficile) is a common causative agent of pseudomembranous colitis (PMC). C. difficile-associated diarrhea (CDAD) ranges from mild diarrhea to life threatening PMC. Recently, a highly virulent strain of C. difficile polymerase chain reaction ribotype 027 was found in North America, Europe, and Japan. A 52-yr-old woman with anti-tuberculosis medication and neurogenic bladder due to traffic accident experienced five episodes of C. difficile PMC after taking antibiotics for pneumonia along with septic shock and acute renal failure. She was readmitted to the intensive care unit and treated with oral vancomycin with refractory of oral metronidazole, inotropics and probiotics for over 60 days. C. difficile isolated both at the first and the last admission was identified as C. difficile ribotype 027 by ribotyping, toxinotyping, and tcdC gene sequencing, which turned out the same pathogen as the epidemic hypervirulent B1/NAP1 strain. This is the first case of C. difficile PCR ribotype 027 in Korea. After discharge, she was maintained on probiotics and rifaximin for 3 weeks. She had no relapse for 6 months. © The Korean Academy of Medical Sciences.
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- 의과대학 > 의학과 > Journal papers
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