Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김형래 | * |
dc.contributor.author | 안정자 | * |
dc.contributor.author | 정혜원 | * |
dc.contributor.author | 이선영 | * |
dc.contributor.author | 문혜성 | * |
dc.date.accessioned | 2016-08-28T12:08:16Z | - |
dc.date.available | 2016-08-28T12:08:16Z | - |
dc.date.issued | 2009 | * |
dc.identifier.issn | 0015-0282 | * |
dc.identifier.other | OAK-5678 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/220193 | - |
dc.description.abstract | Objective: To investigate whether the -1562C>T, R279Q, P574R, and R668Q polymorphisms of the matrix metalloproteinase-9 (MMP-9) gene are related to endometriosis. Design: Case-control study. Setting: University-based hospital in Korea. Patient(s): Patients with endometriosis stage III/IV (n = 225) who underwent pelvic surgery and controls (n = 198) with no endometriosis in a Korean population. Intervention(s): Peripheral blood samples were collected by venipuncture. Main Outcome Measure(s): Frequencies of genotypes and haplotypes were compared with the risk of endometriosis including -1562C>T, R279Q, P574R, and R668Q polymorphisms of MMP-9. Result(s): In the two-locus haplotype analyses using the four single nucleotide polymorphisms (SNPs), an increase in the distribution of the R279Q/P574R (2678G>A/4859C>G) (AC haplotype: odds ratio [OR] = 3.180, 95% confidence interval [CI] = 1.956-5.170; GG haplotype: OR = 4.374, 95% CI = 2.376-8.053) and -1562C>T/R668Q (-1562C>T/5546G>A) (CA haplotype: OR = 3.280, 95% CI = 1.406-7.653) haplotypes was significantly associated with endometriosis. By contrast, the risk of endometriosis was not associated with the individual SNPs studied. Conclusion(s): These findings suggest that haplotype analysis was more informative than SNP analysis. The haplotypes in the MMP-9 gene may correlate with the progression of endometriosis, and further study of these variations might improve our understanding of the pathogenesis of endometriosis. © 2009 American Society for Reproductive Medicine. | * |
dc.language | English | * |
dc.title | Haplotype analysis of the matrix metalloproteinase-9 gene associated with advanced-stage endometriosis | * |
dc.type | Article | * |
dc.relation.issue | 6 | * |
dc.relation.volume | 91 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 2324 | * |
dc.relation.lastpage | 2330 | * |
dc.relation.journaltitle | Fertility and Sterility | * |
dc.identifier.doi | 10.1016/j.fertnstert.2008.03.047 | * |
dc.identifier.wosid | WOS:000266801400006 | * |
dc.identifier.scopusid | 2-s2.0-67349179043 | * |
dc.author.google | Han Y.J. | * |
dc.author.google | Kim H.-N. | * |
dc.author.google | Yoon J.-K. | * |
dc.author.google | Yi S.Y. | * |
dc.author.google | Moon H.-S. | * |
dc.author.google | Ahn J.J. | * |
dc.author.google | Kim H.-L. | * |
dc.author.google | Chung H.W. | * |
dc.contributor.scopusid | 김형래(57202558385;57219111690;57567109600) | * |
dc.contributor.scopusid | 안정자(7403019711) | * |
dc.contributor.scopusid | 정혜원(56499737200) | * |
dc.contributor.scopusid | 이선영(7201404669;56218479400) | * |
dc.contributor.scopusid | 문혜성(14319143700) | * |
dc.date.modifydate | 20240415131357 | * |