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Synthesis of novel trans-stilbene derivatives and evaluation of their potent antioxidant and neuroprotective effects

Title
Synthesis of novel trans-stilbene derivatives and evaluation of their potent antioxidant and neuroprotective effects
Authors
Jung J.-C.Lim E.Lee Y.Kang J.-M.Kim H.Jang S.Oh S.Jung M.
Ewha Authors
오세관김희정
SCOPUS Author ID
오세관scopus; 김희정scopusscopusscopus
Issue Date
2009
Journal Title
European Journal of Medicinal Chemistry
ISSN
0223-5234JCR Link
Citation
vol. 44, no. 8, pp. 3166 - 3174
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
A convenient synthesis and the biological properties of new amides, esters and other derivatives of trans-stilbene are described. The key synthetic strategies involve the Wittig-Horner reaction of a phosphonium salt 9 and an aldehyde 10 to generate (E)- or (Z)-olefins and a coupling reaction of an acid 12 and various amines 13a-n to give trans-stilbene derivatives 15a-n in high yields. A amide derivative 15g showed three times more in vitro free radical-scavenging activity than resveratrol, while another 15d exhibited strong inhibitory activity against lipopolysaccharide (LPS) a-induced NO generation. Allylamide analogue 15a showed the most potent neuroprotective activity in glutamate-induced primary cortical neuron cells. © 2009 Elsevier Masson SAS. All rights reserved.
DOI
10.1016/j.ejmech.2009.03.011
Appears in Collections:
의학전문대학원 > 의학과 > Journal papers
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