View : 15 Download: 0

Biocompatible ceramic nanocarrier for drug delivery with high efficiency

Title
Biocompatible ceramic nanocarrier for drug delivery with high efficiency
Authors
Choi S.-J.Oh J.-M.Choy J.-H.
Ewha Authors
최진호
SCOPUS Author ID
최진호scopus
Issue Date
2009
Journal Title
Nippon Seramikkusu Kyokai Gakujutsu Ronbunshi/Journal of the Ceramic Society of Japan
ISSN
1882-0743JCR Link
Citation
vol. 117, no. 1365, pp. 543 - 549
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Layered double hydroxides, a class of anionic nanoclays, have emerged as drug delivery carriers characterized by an effective uptake mechanism via clathrin-mediated endocytosis and high reservoir capacity. In the present review, the efficacy of an anticancer drug with ceramic nanocarriers, i.e. layered double hydroxides, is discussed in context of the cellular uptake mechanism in cell culture lines and pharmacokinetic and tissue distribution studies in whole animals. In addition, research results on the biodistribution patterns of only fluorescently labeled layered double hydroxides and the subsequent histopathological analysis are described in detail to assess the biocompatibility of layered double hydroxides in vivo. The determination of relationships between delivery efficiency and toxicity can be useful for the rational development of layered double hydroxides as drug delivery systems. © 2009 The Ceramic Society of Japan. All rights reserved.
Appears in Collections:
자연과학대학 > 화학·나노과학전공 > Journal papers
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE