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CD34, RAB20, PU.1 and GFI1 mRNA expression in myelodysplastic syndrome

Title
CD34, RAB20, PU.1 and GFI1 mRNA expression in myelodysplastic syndrome
Authors
Huh H.J.Chae S.L.Lee M.Hong K.S.Mun Y.C.Seong C.M.Chung W.S.Huh J.W.
Ewha Authors
홍기숙이미애정화순성주명허정원문영철
SCOPUS Author ID
홍기숙scopus; 이미애scopus; 정화순scopus; 성주명scopus; 허정원scopus; 문영철scopus
Issue Date
2009
Journal Title
International Journal of Laboratory Hematology
ISSN
1751-5521JCR Link
Citation
vol. 31, no. 3, pp. 344 - 351
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Myelodysplastic syndrome (MDS) with hypocellular bone marrow (BM) is often difficult to distinguish from aplastic anemia (AA). Furthermore, the diagnosis of MDS with low blast counts and normal karyotype may be problematic. These issues highlight the need for a reliable marker for the diagnosis of MDS. This study was conducted to determine if changes of mRNA expression in any of the four selected genes would be useful markers for differentiation of hypoplastic MDS from AA, and MDS from benign disease, as well as to investigate whether mRNA expressions differ between MDS risk subgroups. Thirty-five patients diagnosed with MDS, 27 patients with AA and 17 patients with benign diseases were included. The CD34, RAB20, PU.1 and GFI1 mRNA levels were measured by real-time RT-PCR. The CD34 mRNA expressions in hypoplastic MDS were higher than those found in AA. PU.1 and GFI1 mRNA expressions were significantly lower in MDS with low blast counts and normal karyotype than those of benign disease. High-risk MDS showed higher CD34 expressions than those of low-risk MDS. This study suggests that measurement of CD34 and GFI1 mRNA expressions could be useful as a diagnostic and prognostic marker for MDS. © 2007 Blackwell Publishing Ltd.
DOI
10.1111/j.1751-553X.2008.01056.x
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의학전문대학원 > 의학과 > Journal papers
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