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Different effects of PM10 exposure on preterm birth by gestational period estimated from time-dependent survival analyses

Title
Different effects of PM10 exposure on preterm birth by gestational period estimated from time-dependent survival analyses
Authors
Suh Y.J.Kim H.Seo J.H.Park H.Kim Y.J.Hong Y.C.Ha E.H.
Ewha Authors
하은희김영주박혜숙
SCOPUS Author ID
하은희scopus; 김영주scopus; 박혜숙scopus
Issue Date
2009
Journal Title
International Archives of Occupational and Environmental Health
ISSN
0340-0131JCR Link
Citation
vol. 82, no. 5, pp. 613 - 621
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Purpose: We conducted this study to determine if the preterm risks due to PM10 exposure vary with the exposure periods during pregnancy. This study was also conducted to estimate the different effects of PM10 exposure on preterm birth by exposure periods using the extended Cox model with PM10 exposure as a time-dependent covariate. Methods: We studied birth data obtained from the Korea National Statistical office for 374,167 subjects who were delivered between 1998 and 2000 in Seoul, South Korea. We used PM10 data that was measured hourly to give 24-h averages at 27 monitoring stations in Seoul. The extended Cox model with time-dependent exposure was used to determine if the risk of preterm delivery could be associated with PM10 exposures for each trimester during pregnancy. Results: Effect of PM10 exposure prior to the 37 weeks of gestational period was stronger on the risk of premature birth than that posterior to the 37 weeks of gestational weeks. This trend was consistent for each trimester; however, the hazard ratios for preterm delivery associated with PM10 exposure in the first and third trimester were slightly higher than those of the second trimester. Conclusions: The risk of preterm birth associated with exposure to PM10 differed with the exposure period of the neonates. Therefore, when studying the impact of air pollution exposure during pregnancy, the exposure period during pregnancy should be considered. © Springer-Verlag 2008.
DOI
10.1007/s00420-008-0380-7
Appears in Collections:
의학전문대학원 > 의학과 > Journal papers
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