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Metaplastic squamous carcinoma of the breast: Clinicopathologic analysis of 17 cases [Korean Source]

Title
Metaplastic squamous carcinoma of the breast: Clinicopathologic analysis of 17 cases [Korean Source]
Authors
Lee S.A.Lee K.E.Moon B.I.Han W.S.Sung S.H.
Ewha Authors
한운섭성순희문병인이경은
SCOPUS Author ID
한운섭scopusscopus; 성순희scopus; 문병인scopus; 이경은scopus
Issue Date
2009
Journal Title
Korean Journal of Pathology
ISSN
1738-1843JCR Link
Citation
vol. 43, no. 1, pp. 20 - 25
Indexed
SCOPUS WOS scopus
Abstract
Background: Squamous cell carcinoma of the breast is very rare and it is considered to arise from metaplastic change of ductal carcinoma. Metaplastic squamous cell carcinoma (MSC) of the breast includes pure squamous cell carcinoma, metaplastic adenosquamous carcinoma and low grade adenosquamous carcinoma. Most of the cases of MSC of the breast were reported to have lymph node metastasis and this has a worse prognosis than that of conventional invasive ductal carcinoma. Methods: We collected 17 cases of MSC of the breast from 1,173 cases of breast cancer and analyzed the clinicopathological characteristics. Results: The age range was 31 to 69 years (mean age: 47.2). The mean tumor size was 3.6 cm. Twelve cases (70.6%) had a negative nodal status. The majority of the cases were of a high nuclear grade (grade III: 76.5%), and a high histologic grade (grade III: 88.2%). All the cases had no amplification of HER2, and they were negative for hormonal receptors, except for 2 cases with weak positivity. All the cases showed positivity for EGFR (3+: 14 cases, 1+: 3 cases). Clinical relapse was found in 3 patients on follow up and two of them expired due to lung and bone metastasis. Conclusions: MSC is associated with high nuclear and histologic grades, a high EGFR expression and they are triple negative for ER, PR, and HER2. The EGFR immunopositivity of MSC suggests a basal-like subtype.
DOI
10.4132/KoreanJPathol.2009.43.1.20
Appears in Collections:
의학전문대학원 > 의학과 > Journal papers
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