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dc.contributor.author이원재-
dc.date.accessioned2016-08-28T12:08:09Z-
dc.date.available2016-08-28T12:08:09Z-
dc.date.issued2008-
dc.identifier.issn1016-8478-
dc.identifier.otherOAK-5326-
dc.identifier.urihttp://dspace.ewha.ac.kr/handle/2015.oak/220121-
dc.description.abstractPhenoloxidase (PO), a melanin-forming enzyme around the foreign bodies, is an important component of the host defense system in invertebrates. Pro-PO is the enzymatically inactive zymogen form of PO. In the Drosophila genome, three Pro-PO isoforms have been identified to date. These include Pro-PO1 and 2, which are primarily expressed in crystal cells, and Pro-PO3, which is predominantly found in the lamellocytes. In this study, we demonstrated that Drosophila Pro-PO3, but not Pro-PO1 or 2, is enzymatically active in its zymogen form. These findings were evidenced by spectacular melanin forming capacities of various cells and tissues that overexpressed these proenzymes. Furthermore, the melanization phenotype observed in the lamellocyte-enriched hop Tum-1 mutant was drastically reduced in the absence of PPO3, indicating that PPO3 plays a major role in the lamellocyte-mediated spontaneous melanization process. Taken together, these findings indicate that the biochemical properties, activation mode and in vivo role of Pro-PO3 are likely distinct from those of the other two Pro-PO enzymes involved in Drosophila physiology. © 2008 KSMCB.-
dc.languageEnglish-
dc.titleInvolvement of pro-phenoloxidase 3 in lamellocyte-meidated spontaneous melanization in Drosophila-
dc.typeArticle-
dc.relation.issue6-
dc.relation.volume26-
dc.relation.indexSCI-
dc.relation.indexSCIE-
dc.relation.indexSCOPUS-
dc.relation.indexKCI-
dc.relation.startpage606-
dc.relation.lastpage610-
dc.relation.journaltitleMolecules and Cells-
dc.identifier.wosidWOS:000262463000012-
dc.identifier.scopusid2-s2.0-63449131302-
dc.author.googleNam H.-J.-
dc.author.googleJang I.-H.-
dc.author.googleAsano T.-
dc.author.googleLee W.-J.-
dc.date.modifydate20160429000000-
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일반대학원 > 바이오융합과학과 > Journal papers
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