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Significance of secondary structure in nanostructure formation and thermosensitivity of polypeptide block copolymers

Title
Significance of secondary structure in nanostructure formation and thermosensitivity of polypeptide block copolymers
Authors
Choi Y.Y.Joo M.K.Sohn Y.S.Jeong B.
Ewha Authors
손연수정병문
SCOPUS Author ID
손연수scopus; 정병문scopus
Issue Date
2008
Journal Title
Soft Matter
ISSN
1744-683XJCR Link
Citation
vol. 4, no. 12, pp. 2383 - 2387
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Well-defined nanostructural control from biological motifs is gaining attention among materials scientists. We are reporting that the β-sheet structure of l-polyalanine plays a critical role in developing a fibrous nanostructure as well as the sol-to-gel transition of amphiphilic poly(ethylene glycol)-l/or dl-polyalanine diblock copolymers. l-isomers underwent transitions from random coils to β-sheets, and to nanofibers as the polymer concentration increased, whereas the dl-isomer remained as a random coil structure without developing any specific nanostructure. At high polymer concentrations, the aqueous polymer solutions underwent a sol-to-gel transition as the temperature increased, a so called reverse thermal gelation. The l-isomer with a preassembled β-sheet secondary structure facilitates the sol-to-gel transition rather than the dl-isomer with a random coil structure. Thus, only the l-isomer showed a sol-to-gel transition in the physiologically important range of 20-40 °C. This report provides fundamental information on the relationship between hierarchical structures of polypeptides and the thermosensitive sol-gel transition of the polypeptide aqueous solution. © 2008 The Royal Society of Chemistry.
DOI
10.1039/b809116a
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자연과학대학 > 화학·나노과학전공 > Journal papers
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