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Wogonin inhibits microglial cell migration via suppression of nuclear factor-kappa B activity
- Wogonin inhibits microglial cell migration via suppression of nuclear factor-kappa B activity
- Piao H.Z.; Choi I.Y.; Park J.-S.; Kim H.-S.; Cheong J.H.; Son K.H.; Jeon S.J.; Ko K.H.; Kim W.-K.
- Ewha Authors
- 김희선; 박진선
- SCOPUS Author ID
- 김희선; 박진선
- Issue Date
- Journal Title
- International Immunopharmacology
- vol. 8, no. 12, pp. 1658 - 1662
- SCI; SCIE; SCOPUS
- Previously, we and others have demonstrated that wogonin, an active component from the root of Scutellaria baicalensis Georgi, has a neuroprotective effect in cerebral ischemic insult. The neuroprotective effect of wogonin may at least in part be due to its anti-inflammatory properties. Microglial cells, well-known residential macrophages in the central nervous system, migrate to the ischemic lesion and play a pivotal role in the development of chronic inflammation. In the present study, we observed that wogonin potently inhibited microglial migration toward a chemokine, monocyte chemoattractant protein-1 (MCP-1). The anti-migratory effect of wogonin was provoked at nanomolar concentrations, at which wogonin did not significantly inhibit the production of cytokines and chemokines. NF-κB has previously shown to regulate microglial cell migration, and activation of cAMP-signaling pathway has also been associated with inhibition of microglial cell motility. In the present study, wogonin at low micromolar concentrations completely suppressed the activity of NF-κB in MCP-1-stimulated microglia, and NF-κB inhibitors such as N-acetyl cysteine and pyrrolidinedithiocarbamate inhibited the MCP-1-induced migration of microglial cells. However, wogonin did not stimulate the production of cAMP in microglial cells. Our results indicate that the anti-inflammatory activity of wogonin is exerted at least in part by suppressing microglial cell motility via inhibition of NF-κB activity. © 2008 Elsevier B.V. All rights reserved.
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