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Different clinical and magnetic resonance imaging features between Charcot-Marie-Tooth disease type 1A and 2A

Title
Different clinical and magnetic resonance imaging features between Charcot-Marie-Tooth disease type 1A and 2A
Authors
Chung K.W.Suh B.C.Shy M.E.Cho S.Y.Yoo J.H.Park S.W.Moon H.Park K.D.Choi K.G.Kim S.Kim S.B.Shim D.S.Kim S.M.Sunwoo I.N.Choi B.O.
Ewha Authors
최경규박기덕유정현최병옥
SCOPUS Author ID
최경규scopus; 박기덕scopus; 유정현scopus
Issue Date
2008
Journal Title
Neuromuscular Disorders
ISSN
0960-8966JCR Link
Citation
vol. 18, no. 8, pp. 610 - 618
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Charcot-Marie-Tooth disease type 1A (CMT1A) is the more frequent cause of demyelinating CMT, and CMT2A is the most common cause of axonal CMT. We conducted a magnetic resonance imaging (MRI) study on 39 CMT1A and 21 CMT2A patients to compare their neuroimaging patterns and correlate with clinical features. CMT1A patients showed selective fatty infiltration with a preference for anterior and lateral compartment muscles, whereas CMT2A patients showed a preference for superficial posterior compartment muscles. Early-onset CMT2A patients showed more severe leg fatty atrophy than late-onset CMT2A patients. In late-onset CMT2A, soleus muscle was the earliest, and most severely affected than the other leg muscles. Selective involvement of intrinsic foot muscles is a characteristic pattern of minimal CMT1A and CMT2A. Our MRI study demonstrates different patterns of fatty infiltration involving superficial posterior compartment muscles in CMT2A (partial T-type), and peroneal nerve innervated muscles in CMT1A (P-type). © 2008 Elsevier B.V. All rights reserved.
DOI
10.1016/j.nmd.2008.05.012
Appears in Collections:
의학전문대학원 > 의학과 > Journal papers
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