Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 장중현 | * |
dc.date.accessioned | 2016-08-28T12:08:02Z | - |
dc.date.available | 2016-08-28T12:08:02Z | - |
dc.date.issued | 2008 | * |
dc.identifier.issn | 1027-3719 | * |
dc.identifier.other | OAK-5029 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/220054 | - |
dc.description.abstract | SETTING: We recently showed that treatment failure rate was higher among multidrug-resistant tuberculosis (MDR-TB) patients without a previous history of tuberculosis (TB) treatment, or so-called 'primary resistance'. OBJECTIVE: To investigate the phosphorylation levels of signal transducers and activators of transcription-1 (STAT-1) and STAT-4 and the subsequent cytokine release as a possible cause of a poor prognosis in MDR-TB patients with primary resistance. DESIGN: Ten patients with successfully treated pulmonary TB without resistance, 12 MDR-TB patients with acquired resistance and 10 MDR-TB patients with primary resistance were enrolled. After 24 h stimulation of peripheral blood mononuclear cells (PBMC) with interferon-gamma (IFN-γ), interleukin-12 (IL-12), purified protein derivative (PPD), or lysate of Mycobacteriutn tuberculosis, flow cytometric analysis of intracellular pSTAT-1 and pSTAT-4 were performed and secretion of IFN-γ, IL-12p40 and tumour necrosis factor-alpha (TNF-α) was measured in culture supernatant. RESULTS: The mean fluorescent intensities of pSTAT-1 and pSTAT-4 in PBMC of MDR-TB patients with primary resistance decreased on stimulation of IFN-γ, PPD or lysate of M. tuberculosis when compared with patients with acquired resistance. In addition, secretion of IFN-γ, IL-12p40 and TNF-α in these patients decreased on various stimuli. CONCLUSION: Decreased phosphorylation of STAT-1, STAT-4, and of subsequent cytokine release, might be associated with a poor prognosis in MDR-TB patients with primary resistance. | * |
dc.language | English | * |
dc.title | Decreased phosphorylation of STAT-1, STAT-4 and cytokine release in MDR-TB patients with primary resistance | * |
dc.type | Article | * |
dc.relation.issue | 9 | * |
dc.relation.volume | 12 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 1071 | * |
dc.relation.lastpage | 1076 | * |
dc.relation.journaltitle | International Journal of Tuberculosis and Lung Disease | * |
dc.identifier.wosid | WOS:000258857500016 | * |
dc.identifier.scopusid | 2-s2.0-51149095389 | * |
dc.author.google | Kim H.J. | * |
dc.author.google | Chung D.H. | * |
dc.author.google | Kim M.J. | * |
dc.author.google | Jang J.H. | * |
dc.author.google | Kim Y.W. | * |
dc.author.google | Han S.K. | * |
dc.author.google | Shim Y.-S. | * |
dc.author.google | Yim J.-J. | * |
dc.contributor.scopusid | 장중현(57193227620) | * |
dc.date.modifydate | 20240415132519 | * |