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Synthesis of 2-alkynyl substituted 4′-thioadenosine derivatives and their binding affinities at the adenosine receptors

Title
Synthesis of 2-alkynyl substituted 4′-thioadenosine derivatives and their binding affinities at the adenosine receptors
Authors
Liang C.-W.Choi W.J.Jeong L.S.
Ewha Authors
정낙신최원준
Issue Date
2008
Journal Title
Archives of Pharmacal Research
ISSN
0253-6269JCR Link
Citation
vol. 31, no. 8, pp. 973 - 977
Indexed
SCIE; SCOPUS; KCI WOS scopus
Abstract
On the basis of high binding affinity of 2-hexynyl-N 6- methyladenosine and N 6-substituted-4′-thioadenosine derivatives at the A3 adenosine receptor (AR), novel 2-alkynyl-substituted-N 6-methyl-4′-thioadenosine derivatives, combining the characteristics of two classes of nucleosides were designed and synthesized from D-gulonic γ-lactone via palladium-catalyzed cross coupling reaction as a key step. Among compounds tested, only compound 3b showed moderate binding affinity at the human A3 adenosine receptor without binding affinities at other subtypes. © 2008 The Pharmaceutical Society of Korea.
DOI
10.1007/s12272-001-1254-x
Appears in Collections:
약학대학 > 약학과 > Journal papers
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