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Syndecan-4 regulates platelet-derived growth factor-mediated MAP kinase activation by altering intracellular reactive oxygen species

Title
Syndecan-4 regulates platelet-derived growth factor-mediated MAP kinase activation by altering intracellular reactive oxygen species
Authors
Kim J.Lee J.-h.Park H.S.Hwang J.Han I.-O.Bae Y.S.Oh E.-S.
Ewha Authors
배윤수오억수이정현
SCOPUS Author ID
배윤수scopus; 오억수scopus
Issue Date
2008
Journal Title
FEBS Letters
ISSN
0014-5793JCR Link
Citation
vol. 582, no. 18, pp. 2725 - 2730
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
The cell adhesion receptor, syndecan-4, regulates cellular interactions with both the extracellular matrix and soluble ligands. Accumulating evidence also suggests that cell adhesion is involved in generating reactive oxygen species (ROS). Here, we investigated the role of syndecan-4 in regulating growth factor-induced ROS generation. Rat embryo fibroblasts (REFs) overexpressing syndecan-4 exhibited increased ROS levels compared to control cells. Expression of the non-phagocytic NADH oxidase component Nox1 was increased in syndecan-4-overexpressing REFs and syndecan-4-mediated ROS generation was diminished when levels of Nox1 were knocked-down with small inhibitory RNAs. In addition, syndecan-4 enhanced platelet-derived growth factor (PDGF)-induced MAP kinase activity in parallel with ROS generation. Collectively, these data suggest that syndecan-4 regulates PDGF-induced MAP kinase activation by altering ROS generation. © 2008 Federation of European Biochemical Societies.
DOI
10.1016/j.febslet.2008.06.055
Appears in Collections:
자연과학대학 > 생명과학전공 > Journal papers
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