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Multiplex analysis of cytokines in the serum and cerebrospinal fluid of patients with Alzheimer's disease by color-coded bead technology

Title
Multiplex analysis of cytokines in the serum and cerebrospinal fluid of patients with Alzheimer's disease by color-coded bead technology
Authors
Choi C.Jeong J.-H.Jang J.S.Choi K.Kwon J.L.Kwon J.Choi K.-G.Lee J.-S.Kang S.W.
Ewha Authors
최경규강상원최철희권종범정지향
SCOPUS Author ID
최경규scopus; 강상원scopus; 권종범scopus; 정지향scopus
Issue Date
2008
Journal Title
Journal of Clinical Neurology
ISSN
1738-6586JCR Link
Citation
vol. 4, no. 2, pp. 84 - 88
Indexed
SCIE; SCOPUS; KCI WOS scopus
Abstract
Background and purpose: The availability and promise of effective treatments for neurodegenerative disordersare increasing the importance of early diagnosis. Having molecular and biochemical markers of Alzheimer's disease(AD) would complement clinical approaches, and further the goals of early and accurate diagnosis. Combining multiple biomarkers in evaluations significantly increases the sensitivity and specificity of the biochemical tests. Methods: In this study, we used color-coded bead-based Luminex technology to test the potential of using chemokines and cytokines as biochemical markers of AD. We measured the levels of 22 chemokines and cytokines in the serum and cerebrospinal fluid (CSF) of 32 de novo patients (13 controls, 11 AD, and 8 Parkinson's disease [PD]). Results: MCP-1 was the only cytokine detectable in CSF, and its levels did not differ between control and disease groups. However, the serum concentration of eotaxin was significantly higher in AD patients than in the control group. Conclusions: The analysis of multiple inflammatory mediators revealed marginal differences in their CSF and serum concentrations for the differential diagnosis of AD and PD. These results provide evidence that immunological responses are not major contributors to the pathogenesis of AD and PD.
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의학전문대학원 > 의학과 > Journal papers
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