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Characteristics of acute myeloid leukemia without HLA-DR expression.

Title
Characteristics of acute myeloid leukemia without HLA-DR expression.
Authors
Moon H.Lee S.Huh J.Chung W.S.
Ewha Authors
정화순허정원
SCOPUS Author ID
정화순scopus; 허정원scopus
Issue Date
2007
Journal Title
The Korean journal of laboratory medicine
ISSN
1598-6535JCR Link
Citation
vol. 27, no. 5, pp. 313 - 317
Indexed
SCOPUS WOS scopus
Abstract
BACKGROUND: HLA-DR negativity is known to be useful for distinguishing acute promyelocytic leukemia (APL) from other subtypes of AML, but non-APL cases without HLA-DR antigen expression have been reported. The purpose of this study was to evaluate and compare the characteristics of APL, HLA-DR negative non-APL, and HLA-DR positive non-APL cases. METHODS: A total of 114 cases of AML admitted at Ewha Womans University, Mokdong Hospital between March 1997 and June 2006 were included in this study. A diagnosis of AML was made based on the results of morphology, cytochemistry, immunophenotype, cytogenetics, and/or fluorescence in situ hybridization. RESULTS: Among the 114 AML patients, HLA-DR antigen was not expressed in 39 (34%), including 24 non-APL (62%) and 15 APL patients (38%). The HLA-DR negative non-APL group showed higher leukocyte counts and positive rate of CD19 expression than did APL group (P<0.05). The remaining laboratory findings were not statistically different between the HLA-DR negative non-APL and APL groups. CD34 expression was more frequent in the HLA-DR positive non-APL group than in the HLA-DR negative non-APL group and APL group. Of the 24 patients with HLA-DR negative non-APL, 7 patients had disseminated intravascular coagulation and 2 patients showed morphologic features similar to those of APL. CONCLUSIONS: CD19 expression and leukocyte count may be helpful for differentiating HLA-DR negative non-APL from APL. However, the final diagnosis and classification should be confirmed by cytogenetic or molecular studies.
DOI
10.3343/kjlm.2007.27.5.313
Appears in Collections:
의학전문대학원 > 의학과 > Journal papers
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