View : 28 Download: 0

A case of CD45-, CD19- precursor B cell acute lymphoblastic leukemia with an atypical morphology.

Title
A case of CD45-, CD19- precursor B cell acute lymphoblastic leukemia with an atypical morphology.
Authors
Moon H.Huh J.Cho M.S.Chi H.Chung W.S.
Ewha Authors
정화순허정원조민선
SCOPUS Author ID
정화순scopus; 허정원scopus; 조민선scopus
Issue Date
2007
Journal Title
The Korean journal of laboratory medicine
ISSN
1598-6535JCR Link
Citation
vol. 27, no. 4, pp. 253 - 256
Indexed
SCOPUS WOS scopus
Abstract
The differential diagnosis of acute lymphoblastic leukemia (ALL) from other small round blue cell tumors in children is very important for proper treatment, but sometimes difficult. CD45 is expressed on almost all-human leukocytes and not expressed on other small round blue cell tumors. Moreover, CD19 is expressed on all stages of B lineage cells and loss of this antigen is very rare in precursor B-cell ALL. We report a case of ALL with atypical morphology and immunophenotype. A 6-yr-old girl presented with fever and weight loss. Many abnormal cells with variable sized, high nuclearcytoplasmic ratio and distinct nucleoli were counted 23% in bone marrow. The results of immunophenotyping were negative for CD45, CD19, CD10, CD20, CD3, CD5, CD7, CD56/16, CD13, and CD33 and positive for CD22, TdT, and CD34. The immunohistochemical staining of bone marrow biopsies was positive for CD79a, CD10, TdT and CD99. The cytogenetic study showed normal karyotype but amplification of MLL (myeloid/lymphoid or mixed lineage leukemia) gene was suggestive in the fluorescent in situ hybridization. The patient received the standard chemotherapy for acute lymphoblastic leukemia and reached complete remission.
DOI
10.3343/kjlm.2007.27.4.253
Appears in Collections:
의학전문대학원 > 의학과 > Journal papers
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE