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Overexpression of transforming growth factor-β1 in the valvular fibrosis of chronic rheumatic heart disease

Title
Overexpression of transforming growth factor-β1 in the valvular fibrosis of chronic rheumatic heart disease
Authors
Kim L.Do K.K.Woo I.Y.Dong H.S.Ick M.J.Han K.P.Byung C.C.
Ewha Authors
정익모
SCOPUS Author ID
정익모scopus
Issue Date
2008
Journal Title
Journal of Korean Medical Science
ISSN
1011-8934JCR Link
Citation
vol. 23, no. 1, pp. 41 - 48
Indexed
SCI; SCIE; SCOPUS; KCI WOS scopus
Abstract
For the purpose of determining the pathogenic role of transforming growth factor-β1 (TGF-β1) in the mechanism of chronic rheumatic heart disease, we evaluated the expression of TGF-β1, proliferation of myofibroblasts, and changes in extracellular matrix components including collagen and proteoglycan in 30 rheumatic mitral valves and in 15 control valves. High TGF-β1 expression was identified in 21 cases (70%) of rheumatic mitral valves, whereas only 3 cases (20%) of the control group showed high TGF-β1 expression (p<0.001). Additionally, increased proliferation of myofibroblasts was observed in the rheumatic valves. High TGF-β1 expression positively correlated with the proliferation of myofibroblasts (p=0.004), valvular fibrosis (p< 0.001), inflammatory cell infiltration (p=0.004), neovascularization (p=0.007), and calcification (p<0.001) in the valvular leaflets. The ratio of proteoglycan to collagen deposition inversely correlated with TGF-β1 expression in mitral valves (p=0.040). In conclusion, an ongoing inflammatory process, the expression of TGF-β1, and proliferation of myofibroblasts within the valves have a potential role in the valvular fibrosis, calcification, and changes in the extracellular matrix that lead to the scarring sequelae of rheumatic heart disease. Copyright © The Korean Academy of Medical Sciences.
DOI
10.3346/jkms.2008.23.1.41
Appears in Collections:
의학전문대학원 > 의학과 > Journal papers
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