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Exact tests for epidemiological risks under independent negative binomial sampling for rare events in clinical trials

Title
Exact tests for epidemiological risks under independent negative binomial sampling for rare events in clinical trials
Authors
Kang S.-H.
Ewha Authors
강승호
Issue Date
2008
Journal Title
Drug Information Journal
ISSN
0092-8615JCR Link
Citation
vol. 42, no. 2, pp. 115 - 121
Indexed
SCOPUS WOS scopus
Abstract
2 × 2 contingency tables are frequently obtained from independent binomial sampling. However, when the probabilities of the outcome of interest are small, we may use independent negative binomial sampling in which sampling stops after a predetermined number of the outcome of interest occurs. The obtained 2 × 2 contingency tables are likely to be unbalanced, and the asymptotic tests could be unreliable. In this article, we develop exact conditional tests for the risk difference, the risk ratio, and the odds ratio in 2 × 2 contingency tables obtained from independent negative binomial sampling. We investigate the exact unconditional powers of the exact tests. The main advantage of exact test is that it is guaranteed to control type I errors under the nominal level unconditionally. Copyright © 2008 Drug Information Association, Inc.
Appears in Collections:
자연과학대학 > 통계학전공 > Journal papers
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