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No association of the genetic polymorphisms of endothelial nitric oxide synthase, dimethylarginine dimethylaminohydrolase, and vascular endothelial growth factor with preeclampsia in Korean populations

Title
No association of the genetic polymorphisms of endothelial nitric oxide synthase, dimethylarginine dimethylaminohydrolase, and vascular endothelial growth factor with preeclampsia in Korean populations
Authors
Young J.K.Bo H.P.Park H.Jung S.-C.Pang M.-G.Ryu H.-M.Lee K.-S.Eom S.-M.Park H.-Y.
Ewha Authors
김영주박혜숙정성철박보현
SCOPUS Author ID
김영주scopus; 박혜숙scopus; 정성철scopus; 박보현scopus
Issue Date
2008
Journal Title
Twin Research and Human Genetics
ISSN
1832-4274JCR Link
Citation
vol. 11, no. 1, pp. 77 - 83
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
The purpose of this study was to investigate whether there is any association between preeclampsia and eNOS, DDAH, and VEGF gene polymorphisms, and also to search for a possible association between haplotypes in eNOS, DDHA, and VEGF genes and the risk for preeclampsia. DNA was extracted from whole blood of 223 preeclampsia patients and 237 healthy pregnant women. The genotypes were analyzed by a single base primer extension assay using a SNaPShot assay kit. Results were analyzed with the Student's t-test, Chi-square test, and Logistic regression analysis. Haplotype analyses were performed using Haploview 3.2 version. There were no significant differences in genotype or allele frequencies of eNOS, DDAH, and VEGF gene polymorphisms between preeclampsia patients and controls. No increase in the risk of preeclampsia for those genes was observed under any model of inheritance and there were no statistically significant associations between any haplotypes and preeclampsia risk. Polymorphisms in eNOS, DDAH, and VEGF gene do not seem to be risk factors for preeclampsia.
DOI
10.1375/twin.11.1.77
Appears in Collections:
의학전문대학원 > 의학과 > Journal papers
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