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Discovery and molecular engineering of sugar-containing natural product biosynthetic pathways in actinomycetes

Title
Discovery and molecular engineering of sugar-containing natural product biosynthetic pathways in actinomycetes
Authors
Oh T.-J.Mo S.J.Yoon Y.J.Sohng J.K.
Ewha Authors
윤여준모상준
SCOPUS Author ID
윤여준scopus
Issue Date
2007
Journal Title
Journal of Microbiology and Biotechnology
ISSN
1017-7825JCR Link
Citation
vol. 17, no. 12, pp. 1909 - 1921
Indexed
SCIE; SCOPUS; KCI WOS scopus
Abstract
Significant progress has recently been made concerning the engineering of deoxysugar biosynthesis. The biosynthetic gene clusters of several deoxysugars from various polyketides and aminoglycosides-producing microorganisms have been cloned and studied. This review introduces the biosynthetic pathways of several deoxysugars and the generation of novel hybrid macrolide antibiotics via the coexpression of deoxysugar biosynthetic gene cassettes and the substrate-flexible glycosyltransferases in a host organism as well as the production of TDP-deoxysugar derivatives via one-pot enzymatic reactions with the identified enzymes. These recent developments in the engineering of deoxysugars biosynthesis may pave the way to create novel secondary metabolites with potential biological activities. © The Korean Society for Microbiology and Biotechnology.
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자연과학대학 > 화학·나노과학전공 > Journal papers
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