View : 27 Download: 0

Inhibition of DNA methylation is involved in transdifferentiation of myoblasts into smooth muscle cells

Title
Inhibition of DNA methylation is involved in transdifferentiation of myoblasts into smooth muscle cells
Authors
Lee W.J.Kim H.J.
Ewha Authors
이원준
SCOPUS Author ID
이원준scopus
Issue Date
2007
Journal Title
Molecules and Cells
ISSN
1016-8478JCR Link
Citation
vol. 24, no. 3, pp. 441 - 444
Indexed
SCI; SCIE; SCOPUS; KCI WOS scopus
Abstract
Despite the importance of cell fate decisions regulated by epigenetic: programming, no experimental model has been available to study transdifferentiation from myoblasts to smooth muscle cells. In the present study, we show that myoblast cells can be induced to transdifferentiate into smooth muscle cells by modulating-their epigenetic programming. The DNA methylation, inhibitor, zubularine, induced the morphological transformation of C2C12 myoblasts into smooth muscle cells accompanied by de novo synthesis of smooth muscle markers such as smooth muscle α-actin and transgelin. Furthermore, in increase of p21 and decrease of cyclinD1 mRNA were observed following zebularine treatment, pointing to inhibition of cell cycle progression. This system may provide a awful model for studying the early stages of smooth muscle cell differentiation. © KSMCB 2007.
Appears in Collections:
신산업융합대학 > 체육과학부 > Journal papers
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE