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Nanoparticulate platinum(II) anticancer drug: Synthesis and characterization of amphiphilic cyclotriphosphazene-platinum(II) conjugates

Title
Nanoparticulate platinum(II) anticancer drug: Synthesis and characterization of amphiphilic cyclotriphosphazene-platinum(II) conjugates
Authors
Yu J.Y.Jun Y.J.Jang S.H.Lee H.J.Sohn Y.S.
Ewha Authors
손연수이화정
SCOPUS Author ID
손연수scopus; 이화정scopus
Issue Date
2007
Journal Title
Journal of Inorganic Biochemistry
ISSN
0162-0134JCR Link
Citation
vol. 101, no. 41590, pp. 1931 - 1936
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Novel cyclotriphosphazene-platinum(II) conjugates were prepared by hydrolysis and platination of the amphiphilic cyclotriphosphazenes grafted with equimolar hydrophilic methoxy-poly(ethylene glycol) (MPEG) and hydrophobic oligopeptide. These macromolecular conjugates were found to form stable nanoparticles with a mean diameter of approximately 90-200 nm depending on the hydrophobicity of the conjugated (diamine)platinum moieties. The nanoparticulate platinum(II) conjugates have shown temperature and concentration dependent particle sizes. However, the particle sizes of the conjugates were found to decrease to a certain size as the solution concentration was decreased but remained stable even at 10 μM, which is enough for systemic delivery by injection. The conjugates exhibited lower in vitro cytotoxicity than cisplatin but reasonably good activity against selected human tumor cell lines. © 2007 Elsevier Inc. All rights reserved.
DOI
10.1016/j.jinorgbio.2007.07.003
Appears in Collections:
자연과학대학 > 화학·나노과학전공 > Journal papers
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