Cytochrome P450IA1 polymorphisms along with PM10 exposure contribute to the risk of birth weight reduction

Abstract

We explored the effects of particulate matter <10 μm (PM10) exposure along with CYP1A1 polymorphisms of MspI (T6235C) and NcoI (Ile462Val) on reduced birth weight (BW). A prospective cohort study was done with women who delivered from 2001 to 2004 at Ewha Womans University Hospital, Seoul, Korea. We compared the estimated least squares means of BW in the generalized linear model, after adjusting for controlling factors. High PM10 exposure at the 90th percentile level and above during the 1st trimester conferred a significant risk for reduced BW, compared with low PM10 exposure below the 90th percentile level. The effect of high PM10 exposure during the 1st trimester of pregnancy compared with low PM10 exposure was greater for women with MspI TC/CC and NcoI IleVal/ValVal genotypes than for those with MspI TT and NcoI IleIle genotypes. In conclusion, high PM10 exposure during the 1st trimester increased the risk for reduced BW in concert with MspI TC/CC and NcoI IleVal/ValVal genotypes in Korean women. © 2007 Elsevier Inc. All rights reserved.