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Gene expression profile related to prognosis of acute myeloid leukemia

Title
Gene expression profile related to prognosis of acute myeloid leukemia
Authors
Park M.H.Cho S.A.Yoo K.H.Yang M.H.Ahn J.Y.Lee H.S.Lee K.-E.Mun Y.-C.Cho D.H.Seong C.M.Park J.H.
Ewha Authors
성주명이경은문영철
SCOPUS Author ID
성주명scopus; 이경은scopus; 문영철scopus
Issue Date
2007
Journal Title
Oncology Reports
ISSN
1021-335XJCR Link
Citation
vol. 18, no. 6, pp. 1395 - 1402
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Acute myeloid leukemia (AML) is a heterogeneous group of diseases with respect to biology and clinical course. Through genome-wide scanning, we can have an improvement of the diagnosis and assay system of AML. Microarray was performed for the identification of acute myeloid leukemia prognosis. We divided patients into two groups (good prognosis group, GPG and poor prognosis group, PPG) based on differences in the individual reactions to treatment. Gene expression profiles were analyzed using microarray. Among genes up-regulated at least two-fold and down-regulated at least 0.5-fold in HL-60, we chose three up-regulated genes (PPP2CA, ME3, and CCDN2) and three down-regulated genes (GLO1, ANXA2, and BMI1) and confirmed the expression of these six genes by RT-PCR. We created a leukemia-specific subclass microarray, based on the gene expression profiles. Clinical samples from the bone marrow of four patients were hybridized on this microarray. Among the genes selected by the microarray technology, NB4, silenced TRIB3 and overexpressed XRN2 were not differentiated in spite of treatment with ATRA. This indicates that XRN2 and TRIB3 play an important role in cell differentiation. These data provided an expression profile for the diagnosis and prognosis of AML patients and identified candidate genes that might allow the prognosis of AML through the relative comparison of the expression level of genes between GPG and PPG.
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의학전문대학원 > 의학과 > Journal papers
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