View : 16 Download: 0

A survey of community-associated methicillin-resistant Staphylococcus aureus in Korea

Title
A survey of community-associated methicillin-resistant Staphylococcus aureus in Korea
Authors
Kim E.S.Song J.S.Lee H.J.Choe P.G.Park K.H.Cho J.H.Park W.B.Kim S.-H.Bang J.-H.Kim D.-M.Park K.U.Shin S.Lee M.S.Choi H.J.Kim N.J.Kim E.-C.Oh M.-D.Kim H.B.Choe K.W.
Ewha Authors
최희정
SCOPUS Author ID
최희정scopus
Issue Date
2007
Journal Title
Journal of Antimicrobial Chemotherapy
ISSN
0305-7453JCR Link
Citation
vol. 60, no. 5, pp. 1108 - 1114
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Objectives: Methicillin-resistant Staphylococcus aureus (MRSA), originally restricted to hospitals, has emerged as a significant pathogen in the community. Although MRSA accounts for over 60% of S. aureus in tertiary hospitals in Korea, little is known about the epidemiology of community-associated MRSA (CA-MRSA). Methods: From January to July 2005, a hospital laboratory-based survey was conducted in seven community-based or tertiary hospitals. The medical records and Health Insurance Review Agency databases were reviewed and MRSA isolated from patients without apparent risk factors was defined as CA-MRSA. Susceptibilities to 12 antibiotics were tested by the disc diffusion method. SCC mec typing, Panton-Valentine leucocidin (PVL) gene detection and multilocus sequence typing (MLST) were performed according to published protocols. Results: Of 3251 S. aureus, 1900 (58.4%) were MRSA. CA-MRSA accounted for 112 (5.9%) of the MRSA. Of the 112 CA-MRSA isolates, 27 and 33 were found to be pathogens and colonizers, respectively. Fifty-two isolates from the patients with chronic otitis media were classified as 'undetermined'. Most of the 27 CA-MRSA patients had skin and soft tissue infections or acute ear infections. None of the patients died during the study period. Among 72 isolates tested, 64% were multidrug-resistant. SCC mec type IVa was the most common type among the colonizers and pathogens. On MLST analysis, ST72 was predominant, but ST5 and ST239 were prevalent in the 'undetermined' group. None possessed the PVL gene. Conclusions: Despite MRSA-endemic hospital settings, CA-MRSA infectionsare not common in Korea. A new clone of CA-MRSA, ST72-SCC mec type IVa without the PVL gene, is the most common form. © The Author 2007. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved.
DOI
10.1093/jac/dkm309
Appears in Collections:
의학전문대학원 > 의학과 > Journal papers
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE