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Polymorphisms and haplotypes of the gene encoding the estrogen-metabolizing CYP19 gene in Korean women: No association with advanced-stage endometriosis

Title
Polymorphisms and haplotypes of the gene encoding the estrogen-metabolizing CYP19 gene in Korean women: No association with advanced-stage endometriosis
Authors
Hur S.E.Lee S.Lee J.Y.Moon H.-S.Kim H.L.Chung H.W.
Ewha Authors
김형래정혜원문혜성이사라
SCOPUS Author ID
김형래scopus; 정혜원scopus; 문혜성scopus; 이사라scopus
Issue Date
2007
Journal Title
Journal of Human Genetics
ISSN
1434-5161JCR Link
Citation
vol. 52, no. 9, pp. 703 - 711
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
A variety of factors affect the development of endometriosis, including hormonal status and genetic factors. The growth of endometriosis is stimulated by local estrogen production in conjunction with circulating estrogen. The CYP19 gene encodes a steroid aromatase that catalyses the conversion of C-19 androgens to estrogens. This study investigated whether polymorphisms of the CYP19 gene are associated with the risk of advanced endometriosis in Korean women. Blood samples were collected from 224 female patients with endometriosis of stages III and IV, as diagnosed by both pathologic and laparoscopic findings, and from a control group comprising of 188 women undergoing laparoscopic surgery or laparotomy for nonmalignant lesions. Single-nucleotide polymorphisms, restriction fragment length polymorphisms, and tetranucleotide tandem repeat polymorphisms were discriminated by the polymerase chain reaction (PCR). Haplotype analysis was also performed. CYP19 115T>C, 240G>A, and 1531C>T polymorphisms and [TTTA]n tetranucleotide repeat polymorphisms in the CYP19 gene and their haplotypes were not significantly associated with the risk of endometriosis. The risk of endometriosis also did not increase significantly with the number of higher risk alleles of the CYP19 gene. In conclusion, our findings suggest that CYP19 genetic polymorphisms are not associated with advanced-stage endometriosis in Korean women. © 2007 The Japan Society of Human Genetics and Springer.
DOI
10.1007/s10038-007-0174-x
Appears in Collections:
의학전문대학원 > 의학과 > Journal papers
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