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A tetra(l-lysine)-grafted poly(organophosphazene) for gene delivery

Title
A tetra(l-lysine)-grafted poly(organophosphazene) for gene delivery
Authors
Jun Y.J.Kim J.H.Choi S.J.Lee H.J.Jun M.J.Sohn Y.S.
Ewha Authors
손연수이화정
SCOPUS Author ID
손연수scopus; 이화정scopus
Issue Date
2007
Journal Title
Bioorganic and Medicinal Chemistry Letters
ISSN
0960-894XJCR Link
Citation
vol. 17, no. 11, pp. 2975 - 2978
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
In order to develop a new gene delivery vector, a novel cationic poly(organophosphazene) was synthesized by stepwise nucleophilic substitutions of poly(dichlorophosphazene) with a hydrophilic methoxy-poly(ethylene glycol) (MPEG) as a shielding group and a branched tetra(l-lysine), LysLys(LysEt)2, as a cationic moiety. The cationic polymer has shown to form a polyplex by DNA condensation and very low in vitro cytotoxicity probably due to the shielding effect of MPEG, which provides a basis for improving the low gene transfection yield of cationic polyphosphazenes. © 2007 Elsevier Ltd. All rights reserved.
DOI
10.1016/j.bmcl.2007.03.069
Appears in Collections:
자연과학대학 > 화학·나노과학전공 > Journal papers
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