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Heat shock responses for understanding diseases of protein denaturation

Title
Heat shock responses for understanding diseases of protein denaturation
Authors
Kim H.-J.Hwang N.R.Lee K.-J.
Ewha Authors
이공주김희정
SCOPUS Author ID
이공주scopus; 김희정scopusscopusscopus
Issue Date
2007
Journal Title
Molecules and Cells
ISSN
1016-8478JCR Link
Citation
vol. 23, no. 2, pp. 123 - 131
Indexed
SCI; SCIE; SCOPUS; KCI WOS scopus
Abstract
Extracellular stresses induce heat shock response and render cells resistant to lethal stresses. Heat shock response involves induction of heat shock proteins (Hsps). Recently the roles of Hsps in neurodegenerative diseases and cancer are attracting increasing attention and have accelerated the study of heat shock response mechanism. This review focuses on the stress sensing steps, molecules involved in Hsps production, diseases related to Hsp malfunctions, and the potential of proteomics as a tool for understanding the complex signaling pathways relevant to these events. © KSMCB 2007.
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약학대학 > 약학과 > Journal papers
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