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Plasma-treated poly(lactic-co-glycolic acid) nanofibers for tissue engineering

Title
Plasma-treated poly(lactic-co-glycolic acid) nanofibers for tissue engineering
Authors
Park H.Lee K.Y.Lee S.J.Park K.E.Park W.H.
Ewha Authors
이승진
SCOPUS Author ID
이승진scopus
Issue Date
2007
Journal Title
Macromolecular Research
ISSN
1598-5032JCR Link
Citation
vol. 15, no. 3, pp. 238 - 243
Indexed
SCI; SCIE; SCOPUS; KCI WOS scopus
Abstract
Nanofibers were prepared by electrospinning a solution of poly (lactic-co-gly colic acid) (PLGA) and their mean diameter was 340 nm. The PLGA nanofibers were treated with a plasma in the presence of either oxygen or ammonia gas to change their surface characteristics. The hydrophilicity of the electrospun PLGA nanofibers was significantly increased by the gas plasma treatment, as confirmed by contact angle measurements. XPS analysis demonstrated that the chemical composition of the PLGA nanofiber surface was influenced by the plasma treatment, resulting in an increase in the number of polar groups, which contributed to the enhanced surface hydrophilicity. The degradation behavior of the PLGA nanofibers was accelerated by the plasma treatment, and the adhesion and proliferation of mouse fibroblasts on the plasma-treated nanofibers were significantly enhanced. This approach to controlling the surface characteristics of nanofibers prepared from biocompatible polymers could be useful in the development of novel polymeric scaffolds for tissue engineering.
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약학대학 > 약학과 > Journal papers
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