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Sphingosine 1-phosphate and sphingosine kinase activity during chicken embryonic development

Title
Sphingosine 1-phosphate and sphingosine kinase activity during chicken embryonic development
Authors
Choi C.-H.Jeong J.-S.Yoo B.-I.Jin Y.-X.Moon D.-C.Yoo H.-S.Oh S.Hong S.-P.Lee Y.-M.
Ewha Authors
오세관
SCOPUS Author ID
오세관scopus
Issue Date
2007
Journal Title
Archives of Pharmacal Research
ISSN
0253-6269JCR Link
Citation
vol. 30, no. 4, pp. 502 - 506
Indexed
SCIE; SCOPUS; KCI WOS scopus
Abstract
The chicken embryo has been well used in studies of the developmental process, and during development sphingosine and sphingosine 1-phosphate (So1P) are considered critical mediators of cell death and survival. In this study, we compared the sphingolipid contents of chicken embryos during the early embryonic development period from day 3 to day 6. HPLC analyses of sphingosine and So1P in chicken embryos revealed that sphingosine levels were greatly reduced on day 4 whereas So1P levels were not significantly changed. Sphingosine kinase (Sphk) activities, which require sphingosine as substrate to produce So1P, were also greatly reduced on day 4. Collectively, we found sphingosine levels and Sphk activities, but not So1P levels are changed in early stage of chicken embryos development.
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의학전문대학원 > 의학과 > Journal papers
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