Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 박혜경 | * |
dc.contributor.author | 한운섭 | * |
dc.contributor.author | 조민선 | * |
dc.contributor.author | 최희정 | * |
dc.date.accessioned | 2016-08-28T12:08:41Z | - |
dc.date.available | 2016-08-28T12:08:41Z | - |
dc.date.issued | 2007 | * |
dc.identifier.issn | 0003-9985 | * |
dc.identifier.other | OAK-3918 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/219845 | - |
dc.description.abstract | Context. - Kikuchi disease is a self-limiting febrile lymphadenopathy characterized by a patchy area of apoptosis. Kikuchi disease is thought to be caused by a virus, but this has not been clearly demonstrated. Human herpesviruses 6 and 7 (HHV-6 and HHV-7) are lymphotropic viruses that can induce apoptosis in infected lymphocytes. Recently, HHV-8 was reported to be a possible etiologic agent of Kikuchi disease. Objective. - To investigate the incidence of HHV-6, HHV-7, and HHV-8 infection in patients with Kikuchi disease. Design. - Seventy archival tissue specimens (from 50 Kikuchi disease cases and 20 control cases) were tested for the presence of HHV-6 and HHV-7 using a nested polymerase chain reaction, and for the presence of HHV-8 using single-step polymerase chain reaction. Immunohistochemistry for HHV-8 expression was carried out in those cases in which HHV-8 was detected using polymerase chain reaction. Results. - Of the 50 cases with Kikuchi disease, 21 (42%) were HHV-6 positive and 32 (64%) were HHV-7 positive. Eight (40%) of the 20 control cases were HHV-6 positive and 9 (45%) were HHV-7 positive. Both HHV-6 and HHV-7 were detected in 15 (30%) of the cases with Kikuchi disease and in 3 (15%) of the control cases. Three (6%) of the 50 cases of Kikuchi disease were HHV-8 positive but revealed no positive cells on immunohistochemical analysis for HHV-8. Human herpesvirus 8 was not expressed in any of the control cases. Conclusions. - There was no association between the presence of HHV-6 or HHV-7 and Kikuchi disease. Because the HHV-8 genome but not protein was detected in a small proportion of the cases of Kikuchi disease, its potential causative role in this disease should be determined by further studies. | * |
dc.language | English | * |
dc.title | Questionable role of human herpesviruses in the pathogenesis of Kikuchi disease | * |
dc.type | Article | * |
dc.relation.issue | 4 | * |
dc.relation.volume | 131 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 604 | * |
dc.relation.lastpage | 609 | * |
dc.relation.journaltitle | Archives of Pathology and Laboratory Medicine | * |
dc.identifier.wosid | WOS:000245610500018 | * |
dc.identifier.scopusid | 2-s2.0-34147161160 | * |
dc.author.google | Cho M.-S. | * |
dc.author.google | Choi H.J. | * |
dc.author.google | Park H.K. | * |
dc.author.google | Cho S.E. | * |
dc.author.google | Han W.S. | * |
dc.author.google | Yang W.I. | * |
dc.contributor.scopusid | 박혜경(36014150800) | * |
dc.contributor.scopusid | 한운섭(7401899962;24172227800) | * |
dc.contributor.scopusid | 조민선(13205279200) | * |
dc.contributor.scopusid | 최희정(57217262202) | * |
dc.date.modifydate | 20240423081003 | * |