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Anti-inflammatory effects of short chain fatty acids in IFN-γ-stimulated RAW 264.7 murine macrophage cells: Involvement of NF-κB and ERK signaling pathways

Title
Anti-inflammatory effects of short chain fatty acids in IFN-γ-stimulated RAW 264.7 murine macrophage cells: Involvement of NF-κB and ERK signaling pathways
Authors
Park J.-S.Lee E.-J.Lee J.-C.Kim W.-K.Kim H.-S.
Ewha Authors
김희선박진선
SCOPUS Author ID
김희선scopus; 박진선scopus
Issue Date
2007
Journal Title
International Immunopharmacology
ISSN
1567-5769JCR Link
Citation
vol. 7, no. 1, pp. 70 - 77
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
The overactivation of macrophages causes abnormal cell death and chronic inflammatory diseases. Therefore, the modulation of macrophage-mediated cytotoxicity is expected to become a new therapeutic strategy for various inflammatory diseases. In this study, three types of short chain fatty acids (sodium butyrate (NaB), sodium phenylbutyrate (NaPB), sodium phenylacetate (NaPA)) were found to have anti-inflammatory effects in IFN-γ-stimulated RAW 264.7 cells. They inhibited the expression of iNOS, TNF-α, and IL-6 induced by IFN-γ, while they enhanced the expression of the anti-inflammatory cytokine, IL-10. Their potency as anti-inflammatory agents was in the order of NaB > NaPB > NaPA. Further mechanistic studies revealed these three agents to repress the DNA binding and transcriptional activities of NF-κB, which is an important modulator of inflammation. In addition, these agents repressed the IFN-γ-induced ERK1/2 phosphorylation without affecting the Jak/STAT activities. The potency of NF-κB and ERK inhibition was also in the order of NaB > NaPB > NaPA. The results suggest that the NF-κB and ERK signaling pathways are at least in part involved in the anti-inflammatory activities of these SCFAs. Considering that SCFAs are normally present in the body and have few side effects, they might be promising agents for the prevention and/or treatment of various inflammatory diseases. © 2006 Elsevier B.V. All rights reserved.
DOI
10.1016/j.intimp.2006.08.015
Appears in Collections:
의학전문대학원 > 의학과 > Journal papers
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