Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 이선영 | - |
dc.date.accessioned | 2016-08-28T12:08:32Z | - |
dc.date.available | 2016-08-28T12:08:32Z | - |
dc.date.issued | 2006 | - |
dc.identifier.issn | 1007-9327 | - |
dc.identifier.other | OAK-3634 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/219769 | - |
dc.description.abstract | Aim: To investigate the role of the polymorphism of p53 codon 72 in early gastric cancer (EGC) and advanced gastric cancer (AGC) in Korean patients. Methods: DNA was extracted from blood samples of gastric cancer patients (n = 291) and controls (n = 216). In the p53 codon 72 genotypes were determined by PCR RFLP. Results: Patients with gastric cancer had a significantly higher frequency of the homozygous proline (Pro) allele than the control (P = 0.032). Patients with AGC had a significantly higher frequency of the Arg/Arg (arginine) allele (P = 0.038) than EGC and a similar Pro/Pro allele. The signet ring cell type had a higher frequency of the Pro/Pro allele than other types (P = 0.031). The Pro/Pro genotype carries a 3.9-fold increased risk of developing gastric cancer (95% CI, 1.3-15.4, P = 0.039) when compared to Arg/Arg and Arg/Pro genotypes and to develop EGC is a 5.25 fold increased risk (95% CI, 1.8-19.6, P = 0.021). Conclusion: The Pro/Pro genotype of the p53 codon 72 polymorphism carries a higher risk for gastric cancer in general and is also associated with a much higher risk for EGC than AGC. © 2006 The WJG Press. All rights reserved. | - |
dc.language | English | - |
dc.title | A p53 genetic polymorphism of gastric cancer: Difference between early gastric cancer and advanced gastric cancer | - |
dc.type | Article | - |
dc.relation.issue | 40 | - |
dc.relation.volume | 12 | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.startpage | 6536 | - |
dc.relation.lastpage | 6539 | - |
dc.relation.journaltitle | World Journal of Gastroenterology | - |
dc.identifier.wosid | WOS:000241685100016 | - |
dc.identifier.scopusid | 2-s2.0-33750967914 | - |
dc.author.google | Yi S.Y. | - |
dc.author.google | Lee W.J. | - |
dc.contributor.scopusid | 이선영(7201404669;56218479400) | - |
dc.date.modifydate | 20221123111302 | - |