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A p53 genetic polymorphism of gastric cancer: Difference between early gastric cancer and advanced gastric cancer

Title
A p53 genetic polymorphism of gastric cancer: Difference between early gastric cancer and advanced gastric cancer
Authors
Yi S.Y.Lee W.J.
Ewha Authors
이선영
SCOPUS Author ID
이선영scopus
Issue Date
2006
Journal Title
World Journal of Gastroenterology
ISSN
1007-9327JCR Link
Citation
vol. 12, no. 40, pp. 6536 - 6539
Indexed
SCIE; SCOPUS WOS scopus
Abstract
Aim: To investigate the role of the polymorphism of p53 codon 72 in early gastric cancer (EGC) and advanced gastric cancer (AGC) in Korean patients. Methods: DNA was extracted from blood samples of gastric cancer patients (n = 291) and controls (n = 216). In the p53 codon 72 genotypes were determined by PCR RFLP. Results: Patients with gastric cancer had a significantly higher frequency of the homozygous proline (Pro) allele than the control (P = 0.032). Patients with AGC had a significantly higher frequency of the Arg/Arg (arginine) allele (P = 0.038) than EGC and a similar Pro/Pro allele. The signet ring cell type had a higher frequency of the Pro/Pro allele than other types (P = 0.031). The Pro/Pro genotype carries a 3.9-fold increased risk of developing gastric cancer (95% CI, 1.3-15.4, P = 0.039) when compared to Arg/Arg and Arg/Pro genotypes and to develop EGC is a 5.25 fold increased risk (95% CI, 1.8-19.6, P = 0.021). Conclusion: The Pro/Pro genotype of the p53 codon 72 polymorphism carries a higher risk for gastric cancer in general and is also associated with a much higher risk for EGC than AGC. © 2006 The WJG Press. All rights reserved.
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의학전문대학원 > 의학과 > Journal papers
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