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Paraoxonase gene polymorphism and vitamin levels during pregnancy: Relationship with maternal oxidative stress and neonatal birthweights

Title
Paraoxonase gene polymorphism and vitamin levels during pregnancy: Relationship with maternal oxidative stress and neonatal birthweights
Authors
Min J.Park H.Park B.Kim Y.J.Park J.Lee H.Ha E.Park E.Hong Y.C.
Ewha Authors
하은희박은애김영주박혜숙이화영박보현
SCOPUS Author ID
하은희scopus; 박은애scopus; 김영주scopus; 박혜숙scopus; 이화영scopus; 박보현scopus
Issue Date
2006
Journal Title
Reproductive Toxicology
ISSN
0890-6238JCR Link
Citation
vol. 22, no. 3, pp. 418 - 424
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
The aim of this study was to determine the association between maternal oxidative stress and adverse birth outcome, and serum vitamin levels and paraoxonase (PON) polymorphism during pregnancy. We investigated 276 pregnant women who visited a hospital for prenatal care during gestational weeks 24 and 28. We measured serum Vitamins C and E levels and urinary levels of 8-hydroxy-2-deoxyguanosine (8-OH-dG). We determined the presence of a maternal PON polymorphism (Q-to-R substitution at a nucleotide located on 7q21.3) using a polymerase chain reaction-restriction fragment length polymorphism assay. High levels (relative to the median) of Vitamins C and E were associated with a reduced concentration of urinary 8-OH-dG, but increased birthweight and gestational age in subjects with the Q/Q and Q/R types of PON polymorphism. Even with the high-risk PON polymorphism (R/R), the results show that birthweight increased with high levels of Vitamins C and E. Our data demonstrate that oxidative stress and neonatal birthweight are affected by maternal levels of Vitamins C and E in subjects with a PON polymorphism. © 2006 Elsevier Inc. All rights reserved.
DOI
10.1016/j.reprotox.2006.01.003
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의과대학 > 의학과 > Journal papers
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