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Thermosensitive chitosan as an injectable carrier for local drug delivery

Title
Thermosensitive chitosan as an injectable carrier for local drug delivery
Authors
Bae J.W.Go D.H.Park K.D.Lee S.J.
Ewha Authors
이승진
SCOPUS Author ID
이승진scopus
Issue Date
2006
Journal Title
Macromolecular Research
ISSN
1598-5032JCR Link
Citation
vol. 14, no. 4, pp. 461 - 465
Indexed
SCI; SCIE; SCOPUS; KCI WOS scopus
Abstract
Two types of injectable system using thermosensitive chitosan (chitosan-g-NIPAAm), hydrogel and microparticles (MPs)-embedded hydrogel were developed as drug carriers for controlled release and their pharmaceutical potentials were investigated. 5-Fluorouracil (5-FU)-loaded, biodegradable PLGA MPs were prepared by a double emulsion method and then simply mixed with an aqueous solution of thermosensitive chitosan at room temperature. All 5-FU release rates from the hydrogel matrix were faster than bovine serum albumin (BSA), possibly due to the difference in the molecular weight of the drugs. The 5-FU release profile from MPs-embedded hydrogel was shown to reduce the burst effect and exhibit nearly zero-order release behavior from the beginning of each initial stage. Thus, these MPs-embedded hydrogels, as well as thermosensitive chitosan hydrogel, have promising potential as an injectable drug carrier for pharmaceutical applications.
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약학대학 > 약학과 > Journal papers
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