View : 16 Download: 0

Xenopus protein O-fucosyltransferase 1 (XPOFUT1) is important for axial patterning

Title
Xenopus protein O-fucosyltransferase 1 (XPOFUT1) is important for axial patterning
Authors
Yeo C.-Y.
Ewha Authors
여창열
SCOPUS Author ID
여창열scopus
Issue Date
2006
Journal Title
Korean Journal of Genetics
ISSN
0254-5934JCR Link
Citation
vol. 28, no. 2, pp. 179 - 184
Indexed
SCOPUS WOS scopus
Abstract
Protein O-fucosyltransferase 1 (POFUT1) catalyzes the addition of O-fucose to a number of cell surface and secreted proteins containing EGF-like repeats. Drosophila and mouse POFUT1 play crucial roles for modulating notch signaling, and mouse embryos lacking POFUT1 show severe defects in somitogenesis, vasculogenesis, cardiogenesis and neurogenesis. We isolated a cDNA encoding putative protein O-fucosyltransferase from Xenopus laevis and named this cDNA as XPOFUT1 based on the sequence homology and functional conservation with human POFUT1. XPOFUT1 is expressed maternally and zygotically. During gastrula stages, it is expressed around the blastopore lip. During tailbud and tadpole stages, the expression of XPOFUT1 is restricted to the brain, eye, branchial arches, pronephros and somites. In order to study the roles of XPOFUT1, we designed a morpholino antisense oligonucleotide (MO) against XPOFUT1. Injection of XPOFUT1 MO caused anterior and posterior truncation of body axis. Our results suggest that XPOFUT1 plays important roles in axial patterning during Xenopus development. © The Genetics Society of Korea.
Appears in Collections:
자연과학대학 > 생명과학전공 > Journal papers
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE