Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 정낙신 | - |
dc.contributor.author | 이상국 | - |
dc.date.accessioned | 2016-08-28T11:08:06Z | - |
dc.date.available | 2016-08-28T11:08:06Z | - |
dc.date.issued | 2006 | - |
dc.identifier.issn | 0968-0896 | - |
dc.identifier.other | OAK-3414 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/219720 | - |
dc.description.abstract | A large series of N6-substituted-4′-thioadenosines were synthesized starting from d-gulonic-γ-lactone, and structure-activity relationships were studied at the human A3 and other subtypes of adenosine receptors (ARs). 2-Chloro-substituted and 2-H analogues were compared. 2-Chloro-N6-methyl-4′-thioadenosine 19b was a highly potent and selective agonist (Ki = 0.8 ± 0.1 nM in binding) at the A3AR, and displayed the same relative efficacy in receptor activation as a known full agonist, Cl-IB-MECA. Most of N6-substituted-4′-thioadenosines were less potent in binding than the corresponding N6-substituted-adenosines or N6-substituted-4′-thioadenosine-5′-uronamides. N6-(3-Iodobenzyl) derivative 19g was demonstrated to be an A3AR-selective partial agonist displaying a Ki value of 3.2 nM. © 2006 Elsevier Ltd. All rights reserved. | - |
dc.language | English | - |
dc.title | Design, synthesis, and biological activity of N6-substituted-4′-thioadenosines at the human A3 adenosine receptor | - |
dc.type | Article | - |
dc.relation.issue | 14 | - |
dc.relation.volume | 14 | - |
dc.relation.index | SCI | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.startpage | 4718 | - |
dc.relation.lastpage | 4730 | - |
dc.relation.journaltitle | Bioorganic and Medicinal Chemistry | - |
dc.identifier.doi | 10.1016/j.bmc.2006.03.030 | - |
dc.identifier.wosid | WOS:000238698800004 | - |
dc.identifier.scopusid | 2-s2.0-33646865696 | - |
dc.author.google | Jeong L.S. | - |
dc.author.google | Lee H.W. | - |
dc.author.google | Kim H.O. | - |
dc.author.google | Jung J.Y. | - |
dc.author.google | Gao Z.-G. | - |
dc.author.google | Duong H.T. | - |
dc.author.google | Rao S. | - |
dc.author.google | Jacobson K.A. | - |
dc.author.google | Shin D.H. | - |
dc.author.google | Lee J.A. | - |
dc.author.google | Gunaga P. | - |
dc.author.google | Lee S.K. | - |
dc.author.google | Jin D.Z. | - |
dc.author.google | Chun M.W. | - |
dc.author.google | Moon H.R. | - |
dc.contributor.scopusid | 정낙신(16028528200) | - |
dc.contributor.scopusid | 이상국(36067620500) | - |
dc.date.modifydate | 20211210153309 | - |