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Synthesis and evaluation of biological properties of benzylideneacetophenone derivatives

Title
Synthesis and evaluation of biological properties of benzylideneacetophenone derivatives
Authors
Oh S.Jang S.Kim D.Han I.-O.Jung J.-C.
Ewha Authors
오세관
SCOPUS Author ID
오세관scopus
Issue Date
2006
Journal Title
Archives of Pharmacal Research
ISSN
0253-6269JCR Link
Citation
vol. 29, no. 6, pp. 469 - 475
Indexed
SCIE; SCOPUS; KCI WOS scopus
Abstract
A series of yakuchinone B 1f and its analogs 1a-e was synthesized and evaluated for free radical scavenging, suppression of LPS-induced NO generation, cytotoxicity and anti-excitotoxicity in vitro. Compound 1c exhibited potent anti-excitotoxicity, while all compounds 1a-f showed considerable effects of free radical scavenging, suppression of LPS-induced NO generation, and cytotoxicity in microglia.
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의학전문대학원 > 의학과 > Journal papers
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