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Effect of continuous positive airway pressure versus supplemental oxygen on sleep quality in obstructive sleep apnea: A placebo-CPAP - Controlled study

Title
Effect of continuous positive airway pressure versus supplemental oxygen on sleep quality in obstructive sleep apnea: A placebo-CPAP - Controlled study
Authors
Loredo J.S.Ancoli-Israel S.Lim E.-J.Lim W.J.Dimsdale J.E.
Ewha Authors
임원정
SCOPUS Author ID
임원정scopus
Issue Date
2006
Journal Title
Sleep
ISSN
0161-8105JCR Link
Citation
vol. 29, no. 4, pp. 564 - 571
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Study Objective: We investigated the short-term effectiveness of continuous positive airway pressure (CPAP) and oxygen in improving sleep quality in patients with obstructive sleep apnea (OSA). Design: Randomized, double-blind, placebo-controlled, parallel study. Setting: General Clinical Research Center at a university hospital. Patients: Seventy-six patients with untreated OSA. Interventions: Patients were randomly assigned to 1 of 3 treatments (CPAP, placebo-CPAP, or nocturnal oxygen at 3 L per minute) for 2 weeks. Sleep quality was assessed at baseline and after 1 and 14 days of therapy. Repeated-measures analysis of variance was used to evaluate treatment and time effects, and their interaction. Measurements and Results: Sixty-three patients completed the protocol. When compared with placebo-CPAP and nocturnal oxygen, CPAP increased rapid eye movement (REM) sleep and significantly reduced stage 1 sleep and the number of stage shifts (p < .003). CPAP improved, to within normal limits, the apnea-hypopnea index, total arousal index, and mean oxyhemoglobin saturation (p < .001). The effects of CPAP were apparent during the first night of therapy. Oxygen improved only mean nocturnal saturation (p = .009). CPAP had no significant effect on stage 2 sleep or slow-wave sleep. Conclusions: CPAP was associated with an improvement in sleep quality in patients with OSA by consolidating sleep, reducing stage 1 sleep, and improving REM sleep. CPAP was effective in correcting the respiratory and arousal abnormalities of OSA. The effectiveness of supplemental oxygen was limited to oxyhemoglobin desaturation.
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의학전문대학원 > 의학과 > Journal papers
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