Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 이승신 | - |
dc.date.accessioned | 2016-08-28T11:08:03Z | - |
dc.date.available | 2016-08-28T11:08:03Z | - |
dc.date.issued | 2006 | - |
dc.identifier.issn | 1050-6586 | - |
dc.identifier.other | OAK-3291 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/219688 | - |
dc.description.abstract | Background: Although there have been many therapeutic options for allergic disease, the true allergen desensitization remains a challenging goal. The classic immunotherapy has a limited efficacy, is inconvenient, and has a risk of anaphylaxis. Recent reports revealed that immunostimulatory DNA sequences (ISS-oligdeoxynucleotide [ODN], CpG motif) act as a strong Th1 response-inducing adjuvants and that DNA-based vaccination might be an effective therapeutic option. In this study, we investigate whether ISS-ODN/Dermatophagoides farinae (Der f) conjugate has antiallergic effects in the allergic rhinitis mouse model, sensitive to house-dust mites. Der f is the most common allergen-inducing allergic rhinitis in Korea. Methods: C57BL/6 mice were sensitized with crude extract of Der f. After injection of ISS-ODN or ISS-ODN/Der f conjugate, several parameters of allergic response were evaluated. Results: Scratching and sneezing symptoms and eosinophilic infiltration into nasal mucosa were suppressed by injection with ISS-ODN only and ISS-ODN/Der f conjugate. Interleukin-5 level was decreased and interferon γ level was increased in nasal lavage fluid by injection of ISS-ODN/Der f conjugate. Der f-specific immunoglobulin E was decreased by injection of ISS-ODN or Der f /ISS-ODN conjugate; however, these were not statistically significant. Transforming growthfactor β1 secreted by cultured splenocyte was increased significantly in ISS-ODN/Der f conjugate group. Conclusion: These results suggest ISS-ODN/Der f conjugate induces an antiallergic effect and induces an increase in transforming growth factor β1 level in the allergic rhinitis model using Der f allergen. Allergic response developed by Der f allergen could be more effectively reduced by injection with ISS-ODN/Der f conjugate than by injection with ISS-ODN only. Copyright © 2006, OceanSide Publications, Inc., U.S.A. | - |
dc.language | English | - |
dc.title | Suppression of allergic response by CpG motif oligodeoxynucleotide-house-dust mite conjugate in animal model of allergic rhinitis | - |
dc.type | Article | - |
dc.relation.issue | 2 | - |
dc.relation.volume | 20 | - |
dc.relation.index | SCOPUS | - |
dc.relation.startpage | 212 | - |
dc.relation.lastpage | 218 | - |
dc.relation.journaltitle | American Journal of Rhinology | - |
dc.identifier.wosid | WOS:000237003900020 | - |
dc.identifier.scopusid | 2-s2.0-33646251833 | - |
dc.author.google | Mo J.-H. | - |
dc.author.google | Park S.-W. | - |
dc.author.google | Rhee C.-S. | - |
dc.author.google | Takabayashi K. | - |
dc.author.google | Lee S.S. | - |
dc.author.google | Quan S.-H. | - |
dc.author.google | Kim I.-S. | - |
dc.author.google | Min Y.-G. | - |
dc.author.google | Raz E. | - |
dc.author.google | Lee C.H. | - |
dc.contributor.scopusid | 이승신(8625984100) | - |
dc.date.modifydate | 20211210153418 | - |