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Arsenic trioxide inhibits cell growth in SH-SY5Y and SK-N-AS neuroblastoma cell lines by a different mechanism

Title
Arsenic trioxide inhibits cell growth in SH-SY5Y and SK-N-AS neuroblastoma cell lines by a different mechanism
Authors
Woo S.-Y.Lee M.-Y.Jung Y.-J.Yoo E.-S.Seoh J.-Y.Shin H.-Y.Ahn H.-S.Ryu K.-H.
Ewha Authors
서주영유경하유은선우소연
SCOPUS Author ID
서주영scopus; 유경하scopus; 유은선scopus; 우소연scopus
Issue Date
2006
Journal Title
Pediatric Hematology and Oncology
ISSN
0888-0018JCR Link
Citation
vol. 23, no. 3, pp. 231 - 243
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Neuroblastoma, characterized by heterogeneous cell population, is a common solid tumor in childhood and some malignant neuroblastomas are refractory to conventional chemotherapy. Recently, treatment with arsenic trioxide (As 2 O 3 ) was found effective in the treatment of acute promyelocytic leukemia as well as neuroblastoma cells by inducing apoptosis. To define the mechanism contributing to cell death in those heterogenous cell populations, the authors used two different types of neuroblastoma cells, SH-SY5Y and SK-N-AS, to compare the pathways that mediate death response to arsenic trioxide. With arsenic trioxide exposure, both cell lines were arrested at the S-G2/M phase with the increase of cyclin B expression and CDK1 activity. Although caspase 3 was activated in both cell lines, the NF-?B activity and the expression of cyclin D1, cyclin E, and p27 were different. Therefore, arsenic trioxide could be an effective cytotoxic drug for the treatment of heterogeneous cellular population of neuroblastoma. Copyright © Taylor & Francis Group, LLC.
DOI
10.1080/08880010500506818
Appears in Collections:
의학전문대학원 > 의학과 > Journal papers
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