Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 명기범 | * |
dc.contributor.author | 최혜영 | * |
dc.contributor.author | 최유원 | * |
dc.date.accessioned | 2016-08-28T11:08:02Z | - |
dc.date.available | 2016-08-28T11:08:02Z | - |
dc.date.issued | 2006 | * |
dc.identifier.issn | 0007-0963 | * |
dc.identifier.other | OAK-3211 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/219677 | - |
dc.description.abstract | Background: Extracellular newly identified RAGE-binding protein (EN-RAGE) is a ligand of the receptor for advanced glycation endproducts (RAGE) and has been termed S100A12. The ligation of EN-RAGE with RAGE on the endothelium, mononuclear phagocytes and lymphocytes triggers cellular activation with the generation of the key proinflammatory mediators interleukin (IL)-1β and tumour necrosis factor (TNF)-α. Objectives: The aim of this study was to investigate the presence of RAGE and EN-RAGE, their spatial localization and their coexpression in leprosy lesions. Methods: Immunohistochemistry and confocal laser scanning microscopy were used to evaluate the expression of RAGE and EN-RAGE in leprosy. By enzyme-linked immunosorbent assay, RAGE and EN-RAGE were detected in the serum. Results: (1) In the multibacillary (MB) and paucibacillary (PB) groups, the level of RAGE production was significantly higher than in patients with atypical mycobacterial infection or sarcoidosis (P < 0.01). In the MB group, the production of RAGE was higher than in the PB group (P < 0.01), and it was higher in patients without the lepra reaction than in patients with the lepra reaction (P < 0.05). (2) In MB, PB and atypical mycobacterial infection, the level of EN-RAGE production was significantly higher than in sarcoidosis (P < 0.01). (3) In the confocal laser scanning microscopic examination, the RAGE and EN-RAGE proteins were detected in lepromatous leprosy. These proteins are spatially colocalized along the cell surface, which is in agreement with their receptor-ligand interaction. (4) A comparable amount of EN-RAGE was detected in the serum of the MB and PB groups. Patients with the reaction showed a higher level of EN-RAGE than patients without the reaction in leprosy. Conclusions: Our data suggest that in leprosy, RAGE and EN-RAGE may be involved in the proinflammatory process rather than the antimycobacterial activity, especially during the lepra reaction. The blockade of the interaction of RAGE and EN-RAGE at the early stage of the inflammatory process may minimize the inflammatory response and consequent tissue damage or the sequelae of leprosy. © 2006 British Association of Dermatologists. | * |
dc.language | English | * |
dc.title | The expression of RAGE and EN-RAGE in leprosy | * |
dc.type | Article | * |
dc.relation.issue | 4 | * |
dc.relation.volume | 154 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 594 | * |
dc.relation.lastpage | 601 | * |
dc.relation.journaltitle | British Journal of Dermatology | * |
dc.identifier.doi | 10.1111/j.1365-2133.2005.07112.x | * |
dc.identifier.wosid | WOS:000235891300007 | * |
dc.identifier.scopusid | 2-s2.0-33644873013 | * |
dc.author.google | Kim M.-H. | * |
dc.author.google | Choi Y.W. | * |
dc.author.google | Choi H.Y. | * |
dc.author.google | Myung K.B. | * |
dc.author.google | Cho S.N. | * |
dc.contributor.scopusid | 명기범(7006220296) | * |
dc.contributor.scopusid | 최혜영(55724363200) | * |
dc.contributor.scopusid | 최유원(7404777738) | * |
dc.date.modifydate | 20231120161531 | * |