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Inhibition of telomerase activity in U937 human monocytic leukemia cells by Compound K, a ginseng saponin metabolite
- Inhibition of telomerase activity in U937 human monocytic leukemia cells by Compound K, a ginseng saponin metabolite
- Kang K.A.; Lee K.H.; Chae S.; Kim J.K.; Seo J.Y.; Ham Y.H.; Kim B.J.; Kim H.S.; Kim D.H.; Hyun J.W.
- Ewha Authors
- SCOPUS Author ID
- Issue Date
- Journal Title
- Biotechnology and Bioprocess Engineering
- vol. 11, no. 1, pp. 7 - 12
- SCIE; SCOPUS; KCI
- Telomerase activation is detected in most cancerous cells; hence, telomerase is a highly selective target for cancer therapy, which plays an important role in the apoptotic process. We have previously reported that the ginseng saponin metabolite, Compound K (20-O-D-glucopyranosyl-20(S)-protopanaxadiol, IH901), inhibits cell proliferation by inducing apoptosis and cell cycle arrest at the G1 phase. The present study investigated the regulation of telomerase activity in Compound K treated U937 cells. Compound K treatment caused a reduction in telomerase activity and down-regulated the human telomerase reverse transcriptase (hTERT) gene, resulting in the decreased expressions of its protein, and of the c-Myc and Sp1 proteins (transcription factors of hTERT). These results indicate that the anticancer activity of Compound K could be mediated by inhibition of the telomerase activity. © KSBB.
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