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Inhibition of telomerase activity in U937 human monocytic leukemia cells by Compound K, a ginseng saponin metabolite

Title
Inhibition of telomerase activity in U937 human monocytic leukemia cells by Compound K, a ginseng saponin metabolite
Authors
Kang K.A.Lee K.H.Chae S.Kim J.K.Seo J.Y.Ham Y.H.Kim B.J.Kim H.S.Kim D.H.Hyun J.W.
Ewha Authors
김희선
SCOPUS Author ID
김희선scopus
Issue Date
2006
Journal Title
Biotechnology and Bioprocess Engineering
ISSN
1226-8372JCR Link
Citation
vol. 11, no. 1, pp. 7 - 12
Indexed
SCIE; SCOPUS; KCI WOS scopus
Abstract
Telomerase activation is detected in most cancerous cells; hence, telomerase is a highly selective target for cancer therapy, which plays an important role in the apoptotic process. We have previously reported that the ginseng saponin metabolite, Compound K (20-O-D-glucopyranosyl-20(S)-protopanaxadiol, IH901), inhibits cell proliferation by inducing apoptosis and cell cycle arrest at the G1 phase. The present study investigated the regulation of telomerase activity in Compound K treated U937 cells. Compound K treatment caused a reduction in telomerase activity and down-regulated the human telomerase reverse transcriptase (hTERT) gene, resulting in the decreased expressions of its protein, and of the c-Myc and Sp1 proteins (transcription factors of hTERT). These results indicate that the anticancer activity of Compound K could be mediated by inhibition of the telomerase activity. © KSBB.
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의학전문대학원 > 의학과 > Journal papers
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