Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 박혜영 | - |
dc.contributor.author | 이상국 | - |
dc.date.accessioned | 2016-08-28T11:08:01Z | - |
dc.date.available | 2016-08-28T11:08:01Z | - |
dc.date.issued | 2006 | - |
dc.identifier.issn | 0968-0896 | - |
dc.identifier.other | OAK-3143 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/219665 | - |
dc.description.abstract | To investigate one possible mechanism of action of the cytotoxic activity of benzothiazoles, we synthesized 2-(substituted-phenyl)benzothiazoles and evaluated their ability to inhibit topoisomerase II activities. Solid phase combinatorial method using trityl resin was employed and benzothiazole derivatives with various substitution on 2′-, 3′-, or 4′-position of phenyl group were obtained in ca. 30 mg scale (7-96% yield). Most of the compounds synthesized exhibited topoisomerase II inhibitory activity at 100 μM. 2-(3-Amino-4-methylphenyl)benzothiazole showed high activity (IC50 = 71.7 μM), comparable to etoposide (IC 50 = 78.4 μM). © 2005 Elsevier Ltd. All rights reserved. | - |
dc.language | English | - |
dc.title | Solid phase combinatorial synthesis of benzothiazoles and evaluation of topoisomerase II inhibitory activity | - |
dc.type | Article | - |
dc.relation.issue | 4 | - |
dc.relation.volume | 14 | - |
dc.relation.index | SCI | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.startpage | 1229 | - |
dc.relation.lastpage | 1235 | - |
dc.relation.journaltitle | Bioorganic and Medicinal Chemistry | - |
dc.identifier.doi | 10.1016/j.bmc.2005.09.051 | - |
dc.identifier.wosid | WOS:000234909700038 | - |
dc.identifier.scopusid | 2-s2.0-30344440109 | - |
dc.author.google | Choi S.-J. | - |
dc.author.google | Park H.J. | - |
dc.author.google | Lee S.K. | - |
dc.author.google | Kim S.W. | - |
dc.author.google | Han G. | - |
dc.author.google | Choo H.-Y.P. | - |
dc.contributor.scopusid | 박혜영(34972649500;57200273796) | - |
dc.contributor.scopusid | 이상국(36067620500) | - |
dc.date.modifydate | 20230411110509 | - |