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2-Cys peroxiredoxin function in intracellular signal transduction: Therapeutic implications

Title
2-Cys peroxiredoxin function in intracellular signal transduction: Therapeutic implications
Authors
Kang S.W.Rhee S.G.Chang T.-S.Jeong W.Choi M.H.
Ewha Authors
이서구강상원정우진창동신
SCOPUS Author ID
이서구scopusscopus; 강상원scopus; 정우진scopus; 창동신scopus
Issue Date
2005
Journal Title
Trends in Molecular Medicine
ISSN
1471-4914JCR Link
Citation
vol. 11, no. 12, pp. 571 - 578
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
H 2O 2 is a reactive oxygen species that has drawn much interest because of its role as a second messenger in receptor-mediated signaling. Mammalian 2-Cys peroxiredoxins have been shown to eliminate efficiently the H 2O 2 generated in response to receptor stimulation. 2-Cys peroxiredoxins are members of a novel peroxidase family that catalyze the H 2O 2 reduction reaction in the presence of thioredoxin, thioredoxin reductase and NADPH. Several lines of evidence suggest that 2-Cys peroxiredoxins have dual roles as regulators of the H 2O 2 signal and as defenders of oxidative stress. In particular, 2-Cys peroxiredoxin appears to provide selective, specific and localized control of receptor-mediated signal transduction. Thus, the therapeutic potential of 2-Cys peroxiredoxins is clear for diseases, such as cancer and cardiovascular diseases, that involve reactive oxygen species. © 2005 Elsevier Ltd. All rights reserved.
DOI
10.1016/j.molmed.2005.10.006
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일반대학원 > 생명·약학부 > Journal papers
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