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일반대학원
생명·약학부
Journal papers
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2-Cys peroxiredoxin function in intracellular signal transduction: Therapeutic implications
Title
2-Cys peroxiredoxin function in intracellular signal transduction: Therapeutic implications
Authors
Kang S.W.
;
Rhee S.G.
;
Chang T.-S.
;
Jeong W.
;
Choi M.H.
Ewha Authors
이서구
;
강상원
;
정우진
;
창동신
SCOPUS Author ID
이서구
; 강상원
; 정우진
; 창동신
Issue Date
2005
Journal Title
Trends in Molecular Medicine
ISSN
1471-4914
Citation
Trends in Molecular Medicine vol. 11, no. 12, pp. 571 - 578
Indexed
SCI; SCIE; SCOPUS
Document Type
Review
Abstract
H 2O 2 is a reactive oxygen species that has drawn much interest because of its role as a second messenger in receptor-mediated signaling. Mammalian 2-Cys peroxiredoxins have been shown to eliminate efficiently the H 2O 2 generated in response to receptor stimulation. 2-Cys peroxiredoxins are members of a novel peroxidase family that catalyze the H 2O 2 reduction reaction in the presence of thioredoxin, thioredoxin reductase and NADPH. Several lines of evidence suggest that 2-Cys peroxiredoxins have dual roles as regulators of the H 2O 2 signal and as defenders of oxidative stress. In particular, 2-Cys peroxiredoxin appears to provide selective, specific and localized control of receptor-mediated signal transduction. Thus, the therapeutic potential of 2-Cys peroxiredoxins is clear for diseases, such as cancer and cardiovascular diseases, that involve reactive oxygen species. © 2005 Elsevier Ltd. All rights reserved.
DOI
10.1016/j.molmed.2005.10.006
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